Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. Presents all aspects of biologically active peptides in one resource Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications
Venomous Animals and their Venoms, Volume III: Venomous Invertebrates provides a comprehensive presentation of the entire field of the venomous members of the animal kingdom and chemistry and biochemistry of their venoms, including their pharmacological actions and antigenic properties. This volume focuses on venomous invertebrates, such as insects, centipedes, spiders, scorpions, venomous mollusks, and marine animals. Animals that possess at least one or more venom glands and mechanisms for excretion or extrusion of the venom, as well as apparatus with which to inflict wounds or inject the venomous substances are characterized in this book as “actively venomous , while creatures that have venom glands and venom-excreting ducts, but lack adequate apparatus for inflicting wounds or injecting venom, such as toads, frogs, and salamanders are identified as “passively venomous. This publication is a valuable reference for physicians and veterinarians seeking information on the injuries caused by venomous animals.
Venom in Verse
Author: Gonda A.H. Van Steen
Publisher: Princeton University Press
Aristophanes has enjoyed a conspicuous revival in nineteenth- and twentieth-century Greece. Here, Gonda Van Steen provides the first critical analysis of the role of the classical Athenian playwright in modern Greek culture, explaining how the sociopolitical "venom" of Aristophanes' verses remains relevant and appealing to modern Greek audiences. Deriding or challenging well-known figures and conservative values, Aristophanes' comedies transgress authority and continue to speak to many social groups in Greece who have found in him a witty, pointed, and accessible champion from their "native" tradition. The book addresses the broader issues reflected in the poet's revival: political and linguistic nationalism, literary and cultural authenticity versus creativity, censorship, and social strife. Van Steen's discussion ranges from attitudes toward Aristophanes before and during Greece's War of Independence in the 1820s to those during the Cold War, from feminist debates to the significance of the popular music integrated into comic revival productions, from the havoc transvestite adaptations wreaked on gender roles to the political protest symbolized by Karolos Koun's directorial choices. Crossing boundaries of classical philology, critical theory, and performance studies, the book encourages us to reassess Aristophanes' comedies as both play-acts and modern methods of communication. Van Steen uses material never before accessible in English as she proves that Aristophanes remains Greece's immortal comic genius and political voice.
Heart and Toxins
Author: Dr. Meenakshisundaram Sundaram Ramachandran
The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity. Structured to bring together exploration into the epidemiology, molecular mechanism, pathogenesis, environmental factors and management in cardiovascular toxins Included various topics on cardiovascular toxins such as plant, chemical, animal, nanomaterial and marine biology induced cardiac damage – which are new ideas discussed in detail Comprehensive chapters on the cardiovascular toxicity from drugs, radiotherapy and radiological imaging Enables you to manage multiple clinical cases of cardiovascular toxicity Outlined conclusions at the end of each chapter providing “key learning points to help you organize the chapter’s details without losing insight
Handbook of Proteolytic Enzymes
Author: Alan J. Barrett, J. Fred Woessner, Neil D. Rawlings
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
The World Ayahuasca Diaspora
Author: Beatriz Caiuby Labate, Clancy Cavnar, Alex K. Gearin
Publisher: Taylor & Francis
Ayahuasca is a psychoactive substance that has long been associated with indigenous Amazonian shamanic practices. The recent rise of the drink’s visibility in the media and popular culture, and its rapidly advancing inroads into international awareness, mean that the field of ayahuasca is quickly expanding. This expansion brings with it legal problems, economic inequalities, new forms of ritual and belief, cultural misunderstandings, and other controversies and reinventions. In The World Ayahuasca Diaspora, leading scholars, including established academics and new voices in anthropology, religious studies, and law fuse case-study ethnographies with evaluations of relevant legal and anthropological knowledge. They explore how the substance has impacted indigenous communities, new urban religiosities, ritual healing, international drug policy, religious persecution, and recreational drug milieus. This unique book presents classic and contemporary issues in social science and the humanities, providing rich material on the bourgeoning expansion of ayahuasca use around the globe.
Author: David Watkins
Publisher: Sutton Pub Limited
The de Havilland Venom carried out more operational ground attack sorties than any other RAF aircraft since the Second World War, seeing service as an RAF fighter-bomber between 1952 and 1962. Successor to the Vampire, the Venom was also produced in a two-seat night fighter version, which was developed into the Sea Venom for the Royal Navy. With the co-operation and assistance of many former Service and civilian pilots, the record can finally be set straight in what is the definitive history of this ground-attack, all weather and naval strike fighter. The problems of the trials and development program are discussed, followed by a detailed look at the aircraft's operational service with foreign air forces. The book's tour de force is the comprehensive account of Venom operations during the Suez campaign, the 'Firedog' operations in Malaya, and the protracted anti-terrorist offensive in Aden and Oman. These chapters throw new light on the conflicts and have been compiled from interviews, private papers, and personal accounts. Of particular interest is new information relating to the Sea Venom's career with the Fleet Air Arm. A final chapter covers the use of Venoms as private 'Warbirds' in the UK, New Zealand and the USA.
Natural Toxins 2
Author: Bal Ram Singh, Anthony T. Tu
Publisher: Springer Science & Business Media
From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.
The importance of toxins and other phanuacologically active com pounds obtained from marine animals cannot be emphasized enough. The use of these chemicals for defense or attack of other life fonus are of interest in themselves; however, they are of great importance in our understanding of their mechanisms of action in view of possible application in the defense of man (no doubt a predator) and in biol ogy and medicine. The toxin of the flat fish Pardachirus presented in some of the papers of this book is an example of a defense mechanism based on secretion of a toxin that could possibly be extended to being used to defend man himself from sharks, the marine predators par ex cellence. August, 1984 J. ZADUNAISKY Preface The study of toxins, drugs, and pollutants in the marine environment, and their impact on human life existed already in Babylon and Assyria, Egypt, Persia, India, China, Japan, Greece, Rome and South America. Nevertheless, less is known about ethnic marine biology than about ethnobotany. Only recently however, have active biotoxins been used as molecular probes in neuropharmacology, offering intriguing new insights into nervous activity and muscular functions. It is clear from the presentations at this meeting that much remains to be done, and certainly new, more pharmacologically oriented find ings lie ahead.
The Book of Questions
Author: Gregory Stock
Publisher: Workman Publishing
The phenomenon returns! Originally published in 1987, The Book of Questions, a New York Times bestseller, has been completely revised and updated to incorporate the myriad cultural shifts and hot-button issues of the past twenty-five years, making it current and even more appealing. This is a book for personal growth, a tool for deepening relationships, a lively conversation starter for the family dinner table, a fun way to pass the time in the car. It poses over 300 questions that invite people to explore the most fascinating of subjects: themselves and how they really feel about the world. The revised edition includes more than 100 all-new questions that delve into such topics as the disappearing border between man and machine—How would you react if you learned that a sad and beautiful poem that touched you deeply had been written by a computer? The challenges of being a parent—Would you completely rewrite your child’s college-application essays if it would help him get into a better school? The never-endingly interesting topic of sex—Would you be willing to give up sex for a year if you knew it would give you a much deeper sense of peace than you now have? And of course the meaning of it all—If you were handed an envelope with the date of your death inside, and you knew you could do nothing to alter your fate, would you look? The Book of Questions may be the only publication that challenges—and even changes—the way you view the world, without offering a single opinion of its own.
With all the enormous resources that are invested in medicine, it is sometimes a mystery why there is so much sickness still in evidence. Our life span, though higher than at any time in history, has now leveled off and has not significantly increased in the last two generations. There is a one-third increase in long-term illness in the last 20 years and a 44% increase in cancer incidence, which are not related to demographic issues. In some modern countries, the level of morbidity (defined as days off work because of sickness) has increased by two thirds in this time. Despite $1 trillion spent on cancer research in 20 years, the "War On Cancer" has recently been pronounced a complete failure by the u. s. President's Cancer Panel. Evidently we still have a long way to go. The goal of "Health for All by the Year 2000" as the World Health Organization has put it, is another forgotten dream. As ever, the answer will be found in breaking out of the old philosophical patterns and discovering the new, as yet unacceptable concepts. The problems of medicine today require a Kuhnian breakthrough into new paradigms, and new ways of thinking. And these new ways will not be mere variations of the old, but radical departures. This book, and the conference upon which it was based, is part of a search for these new pathways.